One can arrange statues / other pathway blockers to isolate the slime while still being able to collect the [[Slime Ball]]s.
The trapped slimes are still able to reproduce, and hatched slimes will also be in isolation.
A copper or steel upgraded [[Watering Cans|Watering Can]] would be able to fill the water troughs without entering the isolation area.
[[File:Slime_safe_farm.png|475px|thumb|left|Design for Safe Slime Hutch Farm]]<br>